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摘要:
AIM:To review the clinical response to levetiracetam(LEV)in neonatal seizure management in intensive care unit.METHODS:Medical records of neonates who received LEV from January 2009 to August 2014 were reviewed.Their demographic data,clinical characteristics,etiology,seizures,electroencephalograms,response to treatment and outcome were noted.Literature review of use of LEV in neonates were also performed via PubMed and EMBASE with keywords-“neonates”,“seizures”,“epilepsy”and“LEV”up to Sep 2014 and retrieved the publications.The response rate to LEV was compared.RESULTS:Twelve neonates were identified during the study period.All patients received phenobarbitone loading prior to consideration of LEV.Seven(58%)and nine(75%)achieved seizure freedom 24 h and 72 h after LEV was added,both clinically and electrographically.No serious adverse effects were associated with LEV use.From the literature,there are total 144 neonates reported to have used LEV.The overall results suggested that LEV could control up to 90%of neonatal seizures.CONCLUSION:LEV was found to be relatively safe and efficacious in treating neonatal seizures,but might not work well in the most severe hypoxic ischemic encephalopathy.
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篇名 Response of levetiracetam in neonatal seizures
来源期刊 世界临床儿科杂志 学科 医学
关键词 LEVETIRACETAM PHENOBARBITONE NEONATES Seizures
年,卷(期) 2015,(3) 所属期刊栏目
研究方向 页码范围 45-49
页数 5页 分类号 R
字数 语种
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研究主题发展历程
节点文献
LEVETIRACETAM
PHENOBARBITONE
NEONATES
Seizures
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研究去脉
引文网络交叉学科
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世界临床儿科杂志
不定期
2219-2808
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
134
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0
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