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Neural tube defects(NTDs)are a group of congenital malformations of the central nervous system that are caused by the closure failure of the embryonic neural tube by the 28th day of conception.Anencephaly and spina bifida are the two major subtypes.Fetuses with anencephaly are often stillborn or electively aborted due to prenatal diagnosis,or they die shortly after birth.Most infants with spina bifida are live-born and,with proper surgical treatment,can survive into adulthood.However,these children often have life-long physical disabilities.China has one of the highest prevalence of NTDs in the world.Inadequate dietary folate intake is believed to be the main cause of the cluster.Unlike many other countries that use staple fortification with folic acid as the public health strategy to prevent NTDs,the Chinese government provides all women who have a rural household registration and who plan to become pregnant with folic acid supplements,free of charge,through a nation-wide program started in 2009.Two to three years after the initiation of the program,the folic acid supplementation rate increased to 85%in the areas of the highest NTD prevalence.The mean plasma folate level of women during early and mid-pregnancy doubled the level before the program was introduced.However,most women began taking folic acid supplements when they knew that they were pregnant.This is too late for the protection of the embryonic neural tube.In a postprogram survey of the women who reported folic acid supplementation,less than a quarter of the women began taking supplements prior to pregnancy,indicating that the remaining three quarters of the fetuses remained unprotected during the time of neural tube formation.Therefore,staple food fortification with folic acid should be considered as a priority in the prevention of NTDs.
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篇名 Prevention of neural tube defects with folic acid:The Chinese experience
来源期刊 世界临床儿科杂志 学科 医学
关键词 NEURAL TUBE DEFECTS Folic acid Folate Supplementation FORTIFICATION
年,卷(期) 2015,(3) 所属期刊栏目
研究方向 页码范围 41-44
页数 4页 分类号 R
字数 语种
DOI
五维指标
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研究主题发展历程
节点文献
NEURAL
TUBE
DEFECTS
Folic
acid
Folate
Supplementation
FORTIFICATION
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界临床儿科杂志
不定期
2219-2808
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
134
总下载数(次)
0
总被引数(次)
0
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