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摘要:
Endothelial cells(ECs)are essential for pancreas differentiation,endocrine specification,and endocrine function.They are also involved in the physiopathology of type 1 and type 2 diabetes.During embryogenesis,aortic ECs provide specific factors that maintain the expression of key genes for pancreas development such as pancreatic and duodenal homeobox-1.Other unknown factors are also important for pancreatic endocrine specification and formation of insulin-producing beta cells.Endocrine precursors proliferate interspersed with ductal cells and exocrine precursors and,at some point of development,these endocrine precursors migrate to pancreatic mesenchyme and start forming the islets of Langerhans.By the end of the gestation and close to birth,these islets contain immature beta cells with the capacity to express vascular endothelial growth factor and therefore to recruit ECs from the surrounding microenvironment.ECs in turn produce factors that are essential to maintain insulin secretion in pancreatic beta cells.Once assembled,a cross talk between endocrine cells and ECs maintain the integrity of islets toward an adequate function during the whole life of the adult individual.This review will focus in the EC role in the differentiation and maturation of pancreatic beta cells during embryogenesis as well as the current knowledge about the involvement of endothelium to derive pancreatic beta cells in vitro from mouse or human pluripotent stem cells.
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篇名 Endothelium-derived essential signals involved in pancreas organogenesis
来源期刊 世界实验医学杂志 学科 医学
关键词 ENDOTHELIUM Endothelium-derived SIGNALS DIFFERENTIATION PANCREAS development ORGANOGENESIS
年,卷(期) 2015,(2) 所属期刊栏目
研究方向 页码范围 40-49
页数 10页 分类号 R
字数 语种
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节点文献
ENDOTHELIUM
Endothelium-derived
SIGNALS
DIFFERENTIATION
PANCREAS
development
ORGANOGENESIS
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界实验医学杂志
不定期
2220-315X
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
90
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0
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0
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