论文降重
免费查重
Progress in neuregulin/ErbB signaling and chronic heart failure
基本信息来源于合作网站，原文需代理用户跳转至来源网站获取
摘要：
Heart failure is one of the leading causes of death today.It is a complex clinical syndrome in which the heart has a reduced contraction ability and decreased viable myocytes.Novel approaches to the clinical management of heart failure have been achieved through an understanding of the molecular pathways necessary for normal heart development.Neuregulin-1(NRG-1)has emerged as a potential therapeutic target based on the fact that mice null for NRG-1 or receptors mediating its activity,ErbB2 and ErbB4,are embryonic lethal and exhibit severe cardiac defects.Preclinical studies performed with animal models of heart failure demonstrate that treatment with NRG-1 significantly improves heart function and survival.Clinical data further support NRG-1 as a promising drug candidate for the treatment of cardiac dysfunction in patients.Recent studies have revealed the mechanism underlying the therapeutic effects of NRG-1/ErbB signaling in the treatment of heart failure.Through activation of upstream signaling molecules such as phosphoinositide 3-kinase,mitogen-activated protein kinase,and focal adhesion kinase,NRG-1/ErbB pathway activation results in increased cMLCK expression and enhanced intracellular calcium cycling.The former is a regulator of the contractile machinery,and the latter triggers cell contraction and relaxation.In addition,NRG-1/ErbB signaling also influences energy metabolism and induces epigenetic modification in cardiac myocytes in a way that more closely resembles healthy heart.These observations reveal potentially new treatment options for heart failure.
推荐文章
宫颈癌组织中erbB3、erbB4的表达及意义
宫颈癌
erbB3
erbB4
基因蛋白表达
神经调节因子Neuregulin-1及其受体ErbB2、ErbB4在恒河猴大脑、小脑的表达及分布
恒河猴
大脑
小脑
神经分化因子-1
ErbB受体
Follow ur Heart随心所动
自动变速
骑行
变速器
自行车
Neuregulin-1β对容量超负荷心衰大鼠的治疗作用
Neuregulin-1β
容量超负荷
心力衰竭
心功能
大鼠
内容分析
关键词云
关键词热度
相关文献总数
(/次)
(/年)
引文网络
引文网络
二级参考文献 (0)
共引文献 (0)
参考文献 (0)
节点文献
引证文献 (0)
同被引文献 (0)
二级引证文献 (0)
2015(0)
- 参考文献(0)
- 二级参考文献(0)
- 引证文献(0)
- 二级引证文献(0)
研究主题发展历程
节点文献
ERBB
EPIGENETIC
modification
HEART
failure
METABOLISM
NEUREGULIN-1
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界高血压杂志
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2220-3168
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
邮发代号：
创刊时间：
语种：
出版文献量（篇）
53
总下载数（次）
0
总被引数（次）
0
期刊文献
相关文献
推荐文献
