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Human T-cell lymphotropic virus type 1(HTLV-1)-associated myelopathy/tropical spastic paraparesis(HAM/TSP)is a slowly progressive neurodegenerative disorder in which lesions of the central nervous system cause progressive weakness,stiffness,and a lower limb spastic paraparesis.In some cases,polymyositis,inclusion body myositis,or amyotrophic lateral sclerosis-like syndromes are associated with HTLV-1.TSP was first described in Jamaica in 1888 and known as Jamaican peripheral neuritis before TSP was related to HTLV-1 virus,the first retrovirus being identified,and the disease is since named HAM/TSP.There is no established treatment program for HAM/TSP.Prevention is difficult in lowincome patients(i.e.,HTLV-1 infected breast feeding mothers in rural areas,sex workers).Thus,there is a need for new therapeutic avenues.Therapeutic approaches must be based on a better understanding,not only of clinical and clinicopathological data,but also of the pathophysiology of the affection.Consequently,a better understanding of existing or newly developed animal models of HAM/TSP is a prerequisite step in the development of new treatments.
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篇名 Human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis:Clinical presentation and pathophysiology
来源期刊 世界神经病学杂志 学科 医学
关键词 Tropical spastic PARAPARESIS HUMAN T-CELL lymphotropic VIRUS type-1 Polymyositis Animal models Retroviruses MYELOPATHY HUMAN T-CELL lymphotropic VIRUS type 1-associated MYELOPATHY Pathogenesis
年,卷(期) 2015,(3) 所属期刊栏目
研究方向 页码范围 68-73
页数 6页 分类号 R
字数 语种
DOI
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节点文献
Tropical
spastic
PARAPARESIS
HUMAN
T-CELL
lymphotropic
VIRUS
type-1
Polymyositis
Animal
models
Retroviruses
MYELOPATHY
HUMAN
T-CELL
lymphotropic
VIRUS
type
1-associated
MYELOPATHY
Pathogenesis
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界神经病学杂志
不定期
2218-6212
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
48
总下载数(次)
0
总被引数(次)
0
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