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摘要:
Sarcoidosis is a systemic granulomatous disease of undetermined etiology,and it primarily affects the lungs and lymphatic system but may involve other organs.Recently,there have been several new insights in Japanese patients.The frequency of cardiac,ocular,and cutaneous sarcoidosis has increased in Japan,whereas,the proportion of patients with bilateral hilar lymphadenopathy decreased from 1960 to 2004.Propionibacterium acnes(P.acnes)has been studied extensively as one of the causative microorganism for granuloma formation,particularly in Japan.P.acnes-specific monoclonal antibodies are useful for diagnosing sarcoidosis.The potential association between smoking and sarcoidosis has been evaluated in a Japanese study,which found a higher prevalence of sarcoidosis among young smokers than that in previous reports.Recently,18F-fluorodeoxyglucose positron-emission tomography,which permits visualization of activated inflammation,and endobronchial ultrasonography-guided transbronchial needle aspiration have been increasingly used to diagnose sarcoidosis.Cardiac sarcoidosis is found to be the main cause of death in Japan.The 2006 revised Japanese guidelines for diagnosing cardiac sarcoidosis are useful,particularly for subclinical cardiac sarcoidosis patients.Further studies and international communication and evaluation are needed to determine the causes of sarcoidosis,identify the risk factors for progressive disease,and develop new and effective treatments.
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篇名 Historical transition of management of sarcoidosis
来源期刊 世界呼吸病学杂志 学科 医学
关键词 Japan PROPIONIBACTERIUM acnes Smoking Cardiac SARCOIDOSIS Positron-emission tomography ENDOBRONCHIAL ultrasonography-guided transbronchial needle ASPIRATION
年,卷(期) 2015,(1) 所属期刊栏目
研究方向 页码范围 4-16
页数 13页 分类号 R
字数 语种
DOI
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研究主题发展历程
节点文献
Japan
PROPIONIBACTERIUM
acnes
Smoking
Cardiac
SARCOIDOSIS
Positron-emission
tomography
ENDOBRONCHIAL
ultrasonography-guided
transbronchial
needle
ASPIRATION
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界呼吸病学杂志
不定期
2218-6255
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
66
总下载数(次)
0
总被引数(次)
0
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