Control of stem cell fate by engineering their micro andnanoenvironment

Michelle F Griffin Peter E Butler Alexander M Seifalian Deepak M Kalaskar

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Control of stem cell fate by engineering their micro andnanoenvironment

Control of stem cell fate by engineering their micro andnanoenvironment

作者：

Michelle F Griffin Peter E Butler Alexander M Seifalian Deepak M Kalaskar

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BIOMATERIALS

SCAFFOLD

Stem

cells

Surfacetopography

TISSUE

ENGINEERING

摘要：

Stem cells are capable of long-term self-renewal anddifferentiation into specialised cell types, making theman ideal candidate for a cell source for regenerativemedicine. The control of stem cell fate has become amajor area of interest in the field of regenerative medicineand therapeutic intervention. Conventional methodsof chemically inducing stem cells into specific lineagesis being challenged by the advances in biomaterialtechnology, with evidence highlighting that materialproperties are capable of driving stem cell fate. Materialsare being designed to mimic the clues stem cells receivein their in vivo stem cell niche including topographicaland chemical instructions. Nanotopographical clues thatmimic the extracellular matrix （ECM） in vivo have shownto regulate stem cell differentiation. The delivery of ECMcomponents on biomaterials in the form of short peptidessequences has also proved successful in directing stem celllineage. Growth factors responsible for controlling stemcell fate in vivo have also been delivered via biomaterialsto provide clues to determine stem cell differentiation. Analternative approach to guide stem cells fate is to providegenetic clues including delivering DNA plasmids andsmall interfering RNAs via scaffolds. This review, aims toprovide an overview of the topographical, chemical andmolecular clues that biomaterials can provide to guidestem cell fate. The promising features and challenges ofsuch approaches will be highlighted, to provide directionsfor future advancements in this exciting area of stem celltranslation for regenerative medicine.

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篇名	Control of stem cell fate by engineering their micro andnanoenvironment
来源期刊	世界干细胞杂志：英文版（电子版）	学科	医学
关键词	BIOMATERIALS SCAFFOLD Stem cells Surfacetopography TISSUE ENGINEERING
年，卷（期）	2015,（1）	所属期刊栏目
研究方向		页码范围	37-50
页数	14页	分类号	R
字数		语种
DOI