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AIM:To investigate the associations of dietary acidbase load with prevalent and incident hypertension in community-living Chinese older adults in Hong Kong.METHODS:Participants aged≥65 years participating in a cohort study examining the risk factors for osteoporosis completed a validated food frequency questionnaire(FFQ)at baseline between 2001 and 2003.Estimated net endogenous acid production(NEAP)was calculated using Frassetto’s method based on the diet’s protein to potassium ratio derived from the FFQ.Prevalent and 4-year incident hypertension was defined as systolic blood pressure≥140 mmHg and/or diastolic blood pressure≥90 mmHg and/or self-reported use of anti-hypertensive medications.Multivariable logistic regression was used for cross-sectional analysis(n=3956)to assess the association between estimated NEAP and prevalent hypertension,and for longitudinal analysis(n=795)on its association with 4-year incident hypertension,with adjustment for various potential socio-demographic and lifestyle factors.RESULTS:Median estimated NEAP of the participants was 47.7(interquartile range:36.2,60.9)g/mEq.Participants in the highest quartile of energy-adjusted estimated NEAP was associated with increased likelihood of prevalent hypertension than those in the lowest quartile of energy-adjusted estimated NEAP[multivariable OR=1.66(95%CI:1.22 to 2.26,P trend=0.002)].No significant association was observed between energy-adjusted estimated NEAP and risk of incident hypertension.CONCLUSION:A high dietary acid load was independently associated with an increased likelihood of prevalent hypertension in ambulant older Chinese people in Hong Kong.The longitudinal analyses failed to show any causal relationship between dietary acid load and hypertension in this population.
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篇名 Estimated net endogenous acid production and risk of prevalent and incident hypertension in community-dwelling older people
来源期刊 世界高血压杂志 学科 医学
关键词 ACID-BASE balance COHORT Hypertension Nutrition Chinese
年,卷(期) 2015,(4) 所属期刊栏目
研究方向 页码范围 129-136
页数 8页 分类号 R
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ACID-BASE
balance
COHORT
Hypertension
Nutrition
Chinese
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引文网络交叉学科
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期刊影响力
世界高血压杂志
不定期
2220-3168
北京市朝阳区东四环中路62号楼远洋国际中
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53
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