Cancer stem cell plasticity and tumor hierarchy

Marina Carla Cabrera Robert E Hollingsworth Elaine M Hurt

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Cancer stem cell plasticity and tumor hierarchy

Cancer stem cell plasticity and tumor hierarchy

作者：

Marina Carla Cabrera Robert E Hollingsworth Elaine M Hurt

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Cancer

STEM

cells

STEM

cell

PLASTICITY

Tumor

HIERARCHY

MICROENVIRONMENT

Immune-mediatedtherapies

Epithelial-to-mesenchymal

transition

摘要：

The origins of the complex process of intratumoralheterogeneity have been highly debated and differentcellular mechanisms have been hypothesized to accountfor the diversity within a tumor. The clonal evolution andcancer stem cell （CSC） models have been proposed asdrivers of this heterogeneity. However, the concept ofcancer stem cell plasticity and bidirectional conversionbetween stem and non-stem cells has added additionalcomplexity to these highly studied paradigms and may helpexplain the tumor heterogeneity observed in solid tumors.The process of cancer stem cell plasticity in which cancercells harbor the dynamic ability of shifting from a non-CSCstate to a CSC state and vice versa may be modulated byspecific microenvironmental signals and cellular interactionsarising in the tumor niche. In addition to promoting CSCplasticity, these interactions may contribute to the cellulartransformation of tumor cells and affect response tochemotherapeutic and radiation treatments by providingCSCs protection from these agents. Herein, we review theliterature in support of this dynamic CSC state, discussthe effectors of plasticity, and examine their role in thedevelopment and treatment of cancer.

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篇名	Cancer stem cell plasticity and tumor hierarchy
来源期刊	世界干细胞杂志：英文版（电子版）	学科	医学
关键词	Cancer STEM cells STEM cell PLASTICITY Tumor HIERARCHY MICROENVIRONMENT Immune-mediatedtherapies Epithelial-to-mesenchymal transition
年，卷（期）	2015,（1）	所属期刊栏目
研究方向		页码范围	27-36
页数	10页	分类号	R
字数		语种
DOI