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摘要:
Pseudouridines(Ψs) are the most abundant and highly conserved modified nucleotides found in various stable RNAs of all organisms. Most Ψs are clustered in regions that are functionally important for pre-m RNA splicing. Ψ has an extra hydrogen bond donor that endows RNA molecules with distinct properties that contribute significantly to RNA-mediated cellular processes. Experimental data indicate that spliceosomal sn RNA pseudouridylation can be catalyzed by both RNA-dependent and RNA-independent mechanisms. Recent work has also demonstrated that pseudouridylation can be induced at novel positions under stress conditions, suggesting a regulatory role for Ψ.
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篇名 Insight into the mechanisms and functions of spliceosomal snRNA pseudouridylation
来源期刊 世界生物化学杂志:英文版(电子版) 学科 生物学
关键词 Pre-m RNA SPLICING U2 sn RNA Box H/ACA RIBONUCLEOPROTEIN PSEUDOURIDINE Induced RNA modification
年,卷(期) 2014,(4) 所属期刊栏目
研究方向 页码范围 398-408
页数 11页 分类号 Q522
字数 语种
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Pre-m
RNA
SPLICING
U2
sn
RNA
Box
H/ACA
RIBONUCLEOPROTEIN
PSEUDOURIDINE
Induced
RNA
modification
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研究去脉
引文网络交叉学科
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期刊影响力
世界生物化学杂志:英文版(电子版)
季刊
1949-8454
北京市朝阳区东四环中路62号楼远洋国际中
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391
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0
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