基本信息来源于合作网站,原文需代理用户跳转至来源网站获取       
摘要:
Bladder cancer(BC)is the second urological malignancy in incidence,currently being one of the most neoplasms studied with profile and biology poorly defined.In the world,BC is responsible by about 386000 new cases and 150000 deaths annually with considerable economic impact and high costs for health systems.After its discovery more than 20 years,micro RNAs(miRNAs)have been recognized as molecules that work specifically in post-transcriptional control in majority of eukaryote genomes.MiRNAs are a family of small noncoding RNAs of 19-25 nucleotides in length,expressed in a wide variety of organisms,comprising plants,worms and mammals,including humans.They have a fundamental role in physiological and pathological processes in organs and tissues in a context-dependent manner.This review brings new roles of protective and oncogenic miRNAs linked to carcinogenesis of urothelial carcinoma of the bladder,and associated with behavior of disease.Many studies have demonstrated promising roles of miRNAs working as diagnostic and prognostic biomarkers or involved in target therapies,consolidating miRNAs as crucial players in human cancer.This review allowed a reflection about the true functions of miRNAs in bladder carcinogenesis.Not only by their wide capacities of action,but also by abilities in define the cell date.The future of anti-tumor target therapies will be based not in one,but in groups of miRNAs working together in several steps of carcinogenic process,being able to identify the disease,predicting behavior and effectively treat bladder cancer.
推荐文章
Diffusion in garnet: a review
High temperature and high pressure
Diffusion
Garnet
Point defects
miRNA-21、miRNA-135b、miRNA-141在结肠癌中的表达及其意义
结肠肿瘤
微RNAs
肿瘤标记,生物学
内容分析
关键词云
关键词热度
相关文献总数  
(/次)
(/年)
文献信息
篇名 MiRNA in bladder carcinogenesis:A review
来源期刊 世界临床泌尿杂志 学科 医学
关键词 BLADDER cancer UROTHELIAL CARCINOMA MIRNA Biomarkers
年,卷(期) 2014,(3) 所属期刊栏目
研究方向 页码范围 238-248
页数 11页 分类号 R
字数 语种
DOI
五维指标
传播情况
(/次)
(/年)
引文网络
引文网络
二级参考文献  (0)
共引文献  (0)
参考文献  (0)
节点文献
引证文献  (0)
同被引文献  (0)
二级引证文献  (0)
2014(0)
  • 参考文献(0)
  • 二级参考文献(0)
  • 引证文献(0)
  • 二级引证文献(0)
研究主题发展历程
节点文献
BLADDER
cancer
UROTHELIAL
CARCINOMA
MIRNA
Biomarkers
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界临床泌尿杂志
不定期
2219-2816
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
96
总下载数(次)
0
总被引数(次)
0
论文1v1指导