Chlamydial infections in urological disease:A challenging management

Daniele Tiscione; Francesca Pisano; Paolo Gontero; Paolo Verze; Riccardo Bartoletti; Sandra Mazzoli; Tommaso Cai; Vincenzo Mirone

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Chlamydial infections in urological disease:A challenging management

Chlamydial infections in urological disease:A challenging management

作者：

Daniele Tiscione Francesca Pisano Paolo Gontero Paolo Verze Riccardo Bartoletti Sandra Mazzoli Tommaso Cai Vincenzo Mirone

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CHLAMYDIA

TRACHOMATIS

PROSTATE

Male

FERTILITY

Treatment

Review

摘要：

Chlamydia trachomatis(Ct)infections are the most prevalent sexually transmitted bacterial infections worldwide,causing considerable morbidity and socioeconomic problems.Moreover,Ct infections are asymptomatic in approximately 50%of infected men and 70%of infected women,with the risk for reproductive tract sequelae both in women and men.Recent studies have improved the comprehension of this infection and its natural history,also highlighting its role in decreasing male fertility.Severe complications can be avoided only by a proper early diagnosis and appropriate treatment.We reviewed the literature relating to the new findings in the treatment of Ct infection in sexually active young men.Articles from 1960-2012 were identified through a Medline search using the keywords“Chlamydia trachomatis”combined with“urethritis”,“epididymitis”,“prostatitis”,“treatment”or“management”.Currently,several studies have been published about the role of new antibiotic schedules and new associated compounds in order to improve the efficacy in terms of microbiological results and patient quality of life.In particular,several studies stress the fact that Chlamydia is only metabolically active in the host cell and therefore only targeted intracellularly by antibiotics.Even although the standard therapy includes intracellularly-accumulated antibiotics such as tetracyclines or macrolides,recent evidence highlights the role of quinolones.In particular,recent studies highlight the role of prulifloxacin in the treatment of chronic prostatitis for improving the patient’s quality of life and decreasing the IL-8 level.However,future studies should focus on delineating the natural history of recurrent infections,paying particular attention to treatment failures.

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篇名	Chlamydial infections in urological disease:A challenging management
来源期刊	世界临床泌尿杂志	学科	医学
关键词	CHLAMYDIA TRACHOMATIS PROSTATE Male FERTILITY Treatment Review
年，卷（期）	2014,（1）	所属期刊栏目
研究方向		页码范围	38-43
页数	6页	分类号	R
字数		语种
DOI