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Role ofβ-microseminoprotein from prostate cancer initiation to recurrence:A mini-review
Role ofβ-microseminoprotein from prostate cancer initiation to recurrence:A mini-review
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摘要：
Medline/Pubmed articles relevant to this topic were considered using the search termsβ-microseminoprotein,MSMB,prostate secretory protein of 94 amino acids and PSP94.Full articles were retrieved when the abstract was considered relevant.In addition,other data related to this topic including our own are discussed.Summary of findings-β-microseminoprotein(MSMB)is increasingly being considered as a marker for prostate cancer,as reduced levels have been associated with the disease.Here we review various aspects of this protein including its biological and physiological variants,binding proteins and immune modulation;its importance as a marker for biochemical recurrence of prostate cancer;prostate cancer related splice variants and its therapeutic utility.Two of the most important properties of MSMB are related to anticancer functions and immune modulation.Predominant expression of two(short and full-length)splice variants of MSMB has been observed from normal prostate and several other tissues.In benign prostate hyperplasia the short isoform is dominant,constituting 98%of this isoform,whereas in prostate cancer 96%constitute the fulllength isoform.The MSMB promoter single nucleotide polymorphism rs10993994 with the C allele functions as an activated cyclic adenosine monophosphate response element binding protein binding site.This C variant of rs10993994 could be responsible for the production of splice variants under variable conditions.MSMB has binding motifs to a few known proteins including immunoglobulin G and several Cysteine-rich secretory proteins family proteins.MSMB bound to these proteins is considered as immune modulating.Use of MSMB as a urinary marker for detecting aggressive prostate cancers that could resist radiation and surgical treatments,seems possible,but needs further investigation.The ratio of MSMB splice variants could also be a possible approach in understanding prostate cancers,with higher ratios indicating severe disease.
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| 篇名 | Role ofβ-microseminoprotein from prostate cancer initiation to recurrence:A mini-review | ||
| 来源期刊 | 世界临床泌尿杂志 | 学科 | 医学 |
| 关键词 | β-microseminoprotein ANTICANCER properties Immune modulation SPLICE VARIANTS Promoter single NUCLEOTIDE polymorphism rs10993994 Biochemical RECURRENCE | ||
| 年，卷（期） | 2014,（1） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 20-30 | |
| 页数 | 11页 | 分类号 | R737.25 |
| 字数 | 语种 | ||
| DOI | |||
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β-microseminoprotein
ANTICANCER
properties
Immune
modulation
SPLICE
VARIANTS
Promoter
single
NUCLEOTIDE
polymorphism
rs10993994
Biochemical
RECURRENCE
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研究来源
研究分支
研究去脉
引文网络交叉学科
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世界临床泌尿杂志
主办单位：
百世登出版集团有限公司
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不定期
ISSN：
2219-2816
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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96
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0
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0
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