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AIM:To investigate the relationship between clinicopathological features and bone turnover markers in castration-resistant prostate cancer(CRPC)patients treated with docetaxel.METHODS:Thirty-three patients were enrolled in this study.Serum levels of carboxyterminal cross-linked telopeptide of type 1 collagen generated by metalloproteinases(1CTP)and alkaline phosphatase(ALP)were measured at the start of docetaxel chemotherapy.We examined the relationship between clinicopathological features and serum levels of 1CTP and ALP levels in CRPC patients treated with docetaxel.RESULTS:For the total patient group,the mean±standard deviation(SD)values for docetaxel chemotherapy dose,dose intensity,dosage interval,and number of cycles were 59.3±10.6 mg/m^2,13.9±5.2 mg/m^2 per week,4.7±1.2 wk,and 11.2±7.4,respectively.Fourteen patients died from prostate cancer.Patients were divided into two groups according to mean+SD of serum 1CTP(8.2 ng/mL)and ALP(538.2 IU/L)levels at the start of docetaxel chemotherapy.Patients with lower levels of serum 1CTP and ALP had significantly better survivals than those with higher serum levels(P<0.05).CONCLUSION:Serum levels of 1CTP and ALP are predictors of survival in patients with CRPC who are treated with docetaxel.
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篇名 Bone markers predict survival in castration-resistant prostate cancer patients treated with docetaxel
来源期刊 世界临床泌尿杂志 学科 医学
关键词 Prostate cancer DOCETAXEL chemotherapy Carboxy-terminal PYRIDINOLINE CROSS-LINKED telopeptide parts of type-1 COLLAGEN Alkaline PHOSPHATASE PROGNOSTIC factor
年,卷(期) 2014,(2) 所属期刊栏目
研究方向 页码范围 139-143
页数 5页 分类号 R
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DOI
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研究主题发展历程
节点文献
Prostate
cancer
DOCETAXEL
chemotherapy
Carboxy-terminal
PYRIDINOLINE
CROSS-LINKED
telopeptide
parts
of
type-1
COLLAGEN
Alkaline
PHOSPHATASE
PROGNOSTIC
factor
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界临床泌尿杂志
不定期
2219-2816
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
96
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0
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0
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