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Arsenic-induced abnormalities in glucose metabolism:Biochemical basis and potential therapeutic and nutritional interventions
Arsenic-induced abnormalities in glucose metabolism:Biochemical basis and potential therapeutic and nutritional interventions
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摘要：
Health hazards due to the consumption of heavy metals such as arsenic have become a worldwide problem.Metabolism of arsenic produces various intermediates which are more toxic and cause toxicity.Arsenic exposure results in impairment of glucose metabolism,insulin secretion in pancreaticβ-cells,altered gene expressions and signal transduction,and affects insulinstimulated glucose uptake in adipocytes or skeletal muscle cells.Arsenic toxicity causes abnormalities in glucose metabolism through an increase in oxidative stress.Arsenic interferes with the sulfhydryl groups and phosphate groups present in various enzymes involved in glucose metabolism including pyruvate dehydrogenase andα-ketoglutarate dehydrogenase,and contributes to their impairment.Arsenic inhibits glucose transporters present in the cell membrane,alters expression of genes involved in glucose metabolism,transcription factors and inflammatory cytokines which stimulate oxidative stress.Some theories suggest that arsenic exposure under diabetic conditions inhibits hyperglycemia.However,the exact mechanism behind the behavior of arsenic as an antagonist or synergist on glucose homeostasis and insulin secretion is not yet fully understood.The present review delineates the relationship between arsenic and the biochemical basis of its relationship to glucose metabolism.This review also addresses potential therapeutic and nutritional interventions for attenuating arsenic toxicity.Several other potential nutritional supplements are highlighted in the review that could be used to combat arsenic toxicity.
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ARSENIC
TOXICITY
GLUCOSE
metabolism
NUTRITIONAL
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世界转化医学杂志
主办单位：
百世登出版集团有限公司
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其它
ISSN：
2220-6132
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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48
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0
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0
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