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Assessment of platelet function:Laboratory and point-ofcare methods
Assessment of platelet function:Laboratory and point-ofcare methods
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摘要：
In the event of blood vessel damage,human platelets are promptly recruited on the site of injury and,after their adhesion,activation and aggregation,prevent blood loss with the formation of a clot.The consequence of abnormal regulation can be either hemorrhage or the development of thrombosis.Qualitative and/or quantitative defects in platelets promote bleeding,whereas the residual reactivity of platelets,despite antiplatelet therapies,play an important role in promoting arterial thrombotic complications.Platelet function is traditionally assessed to investigate the origin of a bleeding syndrome,to predict the risk of bleeding prior surgery or during pregnancy or to monitor the efficacy of antiplatelet therapy in thrombotic syndromes that,now,can be considered a new discipline.“Old”platelet function laboratory tests such as the evaluation of bleeding time and the platelet aggregation analysis in platelet-rich plasma are traditionally utilized to aid in the diagnosis and management of patients with platelet and hemostatic disorders and used as diagnostic tools both in bleeding and thrombotic diathesis in specialized laboratories.Now,new and renewed automated systems have been introduced to provide a simple,rapid assessment of platelet function including point of care methods.These new methodologies are also suitable for being used in non-specialized laboratories and in critical area for assessing platelet function in whole blood without the requirement of sample processing.Some of these methods are also beginning to be incorporated into routine clinical use and can be utilized as not only as first panel for the diagnosis of platelet dysfunction,but also for monitoring anti-platelet therapy and to potentially assess risk of both bleeding and/or thrombosis.
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PLATELETS
Method
Test
POINT
of
care
testing
LABORATORY
ASSESSMENT
Bleeding
THROMBOSIS
PLATELET
function
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研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界转化医学杂志
主办单位：
百世登出版集团有限公司
出版周期：
其它
ISSN：
2220-6132
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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出版文献量（篇）
48
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0
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0
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