Oxidative stress and labile plasmatic iron in anemic patients following blood therapy

Carmen Regla Vargas; Félix Alexandre Antunes Soares; Juliana Mezzomo; Luisa Zuravski; Marília Sabo Fernandes; Mushtaq Ahmed; Robson Luiz Puntel; Tatiana Tamborena Rissi; Vanderlei Folmer; Vanusa Manfredini

文献导航

搜索文章

搜索思路

钛学术文献服务平台 \
学术期刊 \
综合期刊 \
其它期刊 \
世界实验医学杂志期刊 \
Oxidative stress and labile plasmatic iron in anemic patients following blood therapy

Oxidative stress and labile plasmatic iron in anemic patients following blood therapy

作者：

Carmen Regla Vargas Félix Alexandre Antunes Soares Juliana Mezzomo Luisa Zuravski Marília Sabo Fernandes Mushtaq Ahmed Robson Luiz Puntel Tatiana Tamborena Rissi Vanderlei Folmer Vanusa Manfredini

基本信息来源于合作网站，原文需代理用户跳转至来源网站获取

ANTIOXIDANT

ENZYMES

Labile

IRON

content

Oxidative

stress

Polytransfused

SUBJECTS

摘要：

AIM:To determine the plasmatic iron content and evaluate the oxidative stress(OS)markers in subjects receiving blood therapy.METHODS:Thirty-nine individuals with unspecified anemia receiving blood transfusions and 15 healthy subjects were included in the study.Anemic subjects were divided into three subgrouP:(1)those that received up to five blood transfusions(n=14);(2)those that received from five to ten transfusions(n=11);and(3)those that received more than ten transfusions(n=14).Blood samples were collected by venous arm puncture and stored in tubes containing heparin.The plasma and cells were separated by centrifugation and subsequently used for analyses.Statistical analyses were performed using Kruskal-Wallis analysis of variance followed by Dunn’s multiple comparison tests when appropriate.RESULTS:The eletrophoretic hemoglobin profiles of the subjects included in this study indicated that no patients presented with hemoglobinopathy.Labile plasmatic iron,ferritin,protein carbonyl,thiobarbituric acidreactive substances(TBARS)and dichlorofluorescein diacetate oxidation were significantly higher(P<0.05),whereas total thiol levels were significantly lower(P<0.05)in transfused subjects compared to controls.Additionally,the activity of catalase,superoxide dismutase and glutathione peroxidase were significantly lower in the transfused subjects(P<0.05).Antioxidant enzyme activities and total thiol levels were positively correlated(P<0.05),and negatively correlated with the levels of protein carbonyl and TBARS(P<0.05).In contrast,protein carbonyl and TBARS were positively correlated(P<0.05).Altogether,these data confirm the involvement of OS in patients following therapy with repeated blood transfusions.CONCLUSION:Our data reveal that changes in OS markers are correlated with levels of labile plasmatic iron and ferritin and the number of transfusions.

内容分析

关键词云

关键词热度

相关文献

推荐文献

根据相关规定，获取原文需跳转至原文服务方进行注册认证身份信息

完成下面三个步骤操作后即可获取文献，阅读后请点击下方页面【继续获取】按钮

钛学术文献服务平台

学术出版新技术应用与公共服务实验室出品

原文合作方

获取文献流程

1.访问原文合作方请等待几秒系统会自动跳转至登录页，首次访问请先注册账号，填写基本信息后，点击【注册】

2.注册后进行实名认证，实名认证成功后点击【返回】

3.检查邮箱地址是否正确，若错误或未填写请填写正确邮箱地址，点击【确认支付】完成获取，文献将在1小时内发送至您的邮箱

*若已注册过原文合作方账号的用户，可跳过上述操作，直接登录后获取原文即可

点击【获取原文】按钮，跳转至合作网站。

首次获取需要在合作网站进行注册。

注册并实名认证，认证后点击【返回】按钮。

确认邮箱信息，点击【确认支付】，订单将在一小时内发送至您的邮箱。

* 若已经注册过合作网站账号，请忽略第二、三步，直接登录即可。

期刊分类
期刊（年）
期刊（期）
期刊推荐

其它

世界实验医学杂志2021 世界实验医学杂志2020 世界实验医学杂志2019 世界实验医学杂志2018 世界实验医学杂志2017 世界实验医学杂志2016 世界实验医学杂志2015 世界实验医学杂志2014 世界实验医学杂志2013 世界实验医学杂志2012 世界实验医学杂志2011

世界实验医学杂志2014年第4期世界实验医学杂志2014年第3期世界实验医学杂志2014年第2期世界实验医学杂志2014年第1期

按字母查找期刊：

A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
其他

联系合作广告推广: shenyukuan@paperpass.com

篇名	Oxidative stress and labile plasmatic iron in anemic patients following blood therapy
来源期刊	世界实验医学杂志	学科	医学
关键词	ANTIOXIDANT ENZYMES Labile IRON content Oxidative stress Polytransfused SUBJECTS
年，卷（期）	2014,（3）	所属期刊栏目
研究方向		页码范围	38-45
页数	8页	分类号	R
字数		语种
DOI