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摘要:
The long term consequence of immunosuppressive therapy in kidney transplantation has prompted investigation of alternative means to modify the immune response to the allograft.Cell based therapies are potentially attractive as they may provide a long lasting immunomodulatory effect,may repair tissues and reduce the necessity to take immunosuppressive drug therapy.Of the current cell therapies,mesenchymal stem cells have now been trialled in small numbers of human kidney transplantation with apparent safety and potential efficacy.Many issues however need to be resolved before these cells will become mainstays of transplant immunosuppression including ex vivo modification to enhance immunomodulatory properties,cell number,route and frequency of administration as well as cellular source of origin.
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篇名 Mesenchymal stem cells for kidney transplantation
来源期刊 世界临床泌尿杂志 学科 医学
关键词 MESENCHYMAL stem cells KIDNEY TRANSPLANTATION IMMUNOSUPPRESSION Solid ORGAN TRANSPLANTATION Cellular THERAPIES
年,卷(期) 2014,(2) 所属期刊栏目
研究方向 页码范围 87-95
页数 9页 分类号 R
字数 语种
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研究主题发展历程
节点文献
MESENCHYMAL
stem
cells
KIDNEY
TRANSPLANTATION
IMMUNOSUPPRESSION
Solid
ORGAN
TRANSPLANTATION
Cellular
THERAPIES
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界临床泌尿杂志
不定期
2219-2816
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
96
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0
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0
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