Oral creatine supplementation:A potential adjunct therapy for rheumatoid arthritis patients

Thomas J Wilkinson; Thomas D O’Brien; Andrew B Lemmey

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Oral creatine supplementation:A potential adjunct therapy for rheumatoid arthritis patients

Oral creatine supplementation:A potential adjunct therapy for rheumatoid arthritis patients

作者：

Thomas J Wilkinson Thomas D O’Brien Andrew B Lemmey

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CREATINE

supplementation

Nutritional

supplement

RHEUMATOID

ARTHRITIS

RHEUMATOID

CACHEXIA

Physical

function

摘要：

Creatine is one of the most popular forms of protein supplements and is known to improve performance in healthy athletic populations via enhanced muscle mass and adenosine triphosphate energy regeneration.Clinical use of creatine may similarly benefit patients with rheumatoid arthritis(RA),an inflammatory condition characterised by generalised muscle loss termed“rheumatoid cachexia”.The adverse consequences of rheumatoid cachexia include reduced strength,physical function and,as a consequence,quality of life.Whilst regular high-intensity exercise training has been shown to increase muscle mass and restore function in RA patients,this form of therapy has very low uptake amongst RA patients.Thus,acceptable alternatives are required.The aim of this review is to consider the potential efficacy of creatine as an anabolic and ergonomic therapy for RA patients.To date,only one study has supplemented RA patients with creatine,and the findings from this investigation were inconclusive.However,trials in populations with similar losses of muscle mass and function as RA,including older adults and those with other muscle wasting conditions,indicate that creatine is an efficacious way of improving muscle mass,strength and physical function,and may offer an easy,safe and cheap means of treating rheumatoid cachexia and its consequences.

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篇名	Oral creatine supplementation:A potential adjunct therapy for rheumatoid arthritis patients
来源期刊	世界风湿病学杂志	学科	医学
关键词	CREATINE supplementation Nutritional supplement RHEUMATOID ARTHRITIS RHEUMATOID CACHEXIA Physical function
年，卷（期）	2014,（3）	所属期刊栏目
研究方向		页码范围	22-34
页数	13页	分类号	R
字数		语种
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