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Pharmacogenetics of type 2 diabetes mellitus:An example of success in clinical and translational medicine
Pharmacogenetics of type 2 diabetes mellitus:An example of success in clinical and translational medicine
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摘要：
The pharmacological interventions currently available to control type 2 diabetes mellitus(T2DM)show a wide interindividual variability in drug response,emphasizing the importance of a personalized,more effective medical treatment for each individual patient.In this context,a growing interest has emerged in recent years and has focused on pharmacogenetics,a discipline aimed at understanding the variability in patients’drug response,making it possible to predict which drug is best for each patient and at what doses.Recent pharmacological and clinical evidences indicate that genetic polymorphisms(or genetic variations)of certain genes can adversely affect drug response and therapeutic efficacy of oral hypoglycemic agents in patients with T2DM,through pharmacokinetic-and/or pharmacodynamic-based mechanisms that may reduce the therapeutic effects or increase toxicity.For example,genetic variants in genes encoding enzymes of the cytochrome P-450 superfamily,or proteins of the ATP-sensitive potassium channel on the beta-cell of the pancreas,are responsible for the interindividual variability of drug response to sulfonylureas in patients with T2DM.Instead,genetic variants in the genes that encode for the organic cation transporters of metformin have been related to changes in both pharmacodynamic and pharmacokinetic responses to metformin in metformin-treated patients.Thus,based on the individual’s genotype,the possibility,in these subjects,of a personalized therapy constitutes the main goal of pharmacogenetics,directly leading to the development of the right medicine for the right patient.Undoubtedly,this represents an integral part of the translational medicine network.
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| 篇名 | Pharmacogenetics of type 2 diabetes mellitus:An example of success in clinical and translational medicine | ||
| 来源期刊 | 世界转化医学杂志 | 学科 | 医学 |
| 关键词 | Type 2 diabetes ANTI-DIABETIC drugs PERSONALIZED therapy Genetic VARIANTS GENOME-WIDE association study | ||
| 年，卷（期） | 2014,（3） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 141-149 | |
| 页数 | 9页 | 分类号 | R |
| 字数 | 语种 | ||
| DOI | |||
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Type
2
diabetes
ANTI-DIABETIC
drugs
PERSONALIZED
therapy
Genetic
VARIANTS
GENOME-WIDE
association
study
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研究分支
研究去脉
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世界转化医学杂志
主办单位：
百世登出版集团有限公司
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其它
ISSN：
2220-6132
CN：
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出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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48
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0
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0
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