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摘要:
Interferon production is an important defence against viral replication and its activation is an attractive therapeutic target. However, it has long been known that viruses perpetually evolve a multitude of strategies to evade these host immune responses. In recent years there has been an explosion of information on virusinduced alterations of the host immune response that have resulted from data-rich omics technologies. Unravelling how these systems interact and determining the overall outcome of the host response to viral infection will play an important role in future treatment and vaccine development. In this review we focus primarily on the interferon pathway and its regulation as well as mechanisms by which respiratory RNA viruses interfere with its signalling capacity.
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篇名 Systems biology unravels interferon responses to respiratory virus infections
来源期刊 世界生物化学杂志:英文版(电子版) 学科 医学
关键词 RESPIRATORY virus INTERFERON Systems biology Proteomics GENOMICS INNATE immunity
年,卷(期) 2014,(1) 所属期刊栏目
研究方向 页码范围 12-25
页数 14页 分类号 R373
字数 语种
DOI
五维指标
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研究主题发展历程
节点文献
RESPIRATORY
virus
INTERFERON
Systems
biology
Proteomics
GENOMICS
INNATE
immunity
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界生物化学杂志:英文版(电子版)
季刊
1949-8454
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
391
总下载数(次)
0
总被引数(次)
0
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