基本信息来源于合作网站,原文需代理用户跳转至来源网站获取       
摘要:
Cerebral ageing is a complex biological process associated with progressing cerebrovascular disease and neuronal death.It does not always,however,associate with a functional decline,as the ageing mammalian brain retains considerable functional plasticity which supports successful cerebral ageing where age-related cognitive decline is modest.On the contrary,pathological cerebral ageing results in memory impairment and cognitive deterioration,with Alzheimer’s disease(AD)being a florid example.Trophic/growth factors promote brain plasticity;among them are peptides which belong to the insulin family.Preclinical research suggests that the evolutionarily conserved brain insulin/insulin-like growth factor-1(IGF-1)signalling system controls lifespan and protects against some features of AD such as neurodegeneration-related accumulation of toxic proteins and cognitive deficiencies,as observed in animal models.Insulin and IGF-1 activate cell signalling mechanisms which play protective and regenerative roles;abnormalities in the insulin/IGF-1 system may trigger a cascade of neurodegeneration in AD.AD patients show cerebral resistance to insulin which associates with IGF-I resistance and dysregulation of insulin/IGF-1 receptors as well as cognitive deterioration.This review is focused on the roles of the insulin/IGF-1 signalling system in cerebral ageing and its potential involvement in neurodegeneration in the human brain as seen against the background of preclinical evidence.
推荐文章
上皮性卵巢癌组织中胰岛素样生长因子1及其相关蛋白的表达分析
上皮性卵巢癌
胰岛素样生长因子1
胰岛素样生长因子1受体
胰岛素样生长因子结合蛋白3
IGFBP -1的生理功能及其表达调控的研究进展
IGFBP-1
生长
IGF信号通路
发育
代谢条件
胰岛素样生长因子-Ⅰ(IGF-Ⅰ)促生长作用的研究进展
胰岛素样生长因子(IGF-Ⅰ)
促生长作用
研究进展
内容分析
关键词云
关键词热度
相关文献总数  
(/次)
(/年)
文献信息
篇名 Cerebral ageing-the role of insulin and insulin-like growth factor signalling:A review
来源期刊 世界神经病学杂志 学科 医学
关键词 Brain INSULIN INSULIN receptor Insulinlike growth factor LONGEVITY Alzheimer’s Diabetes MELLITUS INFLAMMATION
年,卷(期) 2014,(3) 所属期刊栏目
研究方向 页码范围 12-22
页数 11页 分类号 R
字数 语种
DOI
五维指标
传播情况
(/次)
(/年)
引文网络
引文网络
二级参考文献  (0)
共引文献  (0)
参考文献  (0)
节点文献
引证文献  (0)
同被引文献  (0)
二级引证文献  (0)
2014(0)
  • 参考文献(0)
  • 二级参考文献(0)
  • 引证文献(0)
  • 二级引证文献(0)
研究主题发展历程
节点文献
Brain
INSULIN
INSULIN
receptor
Insulinlike
growth
factor
LONGEVITY
Alzheimer’s
Diabetes
MELLITUS
INFLAMMATION
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界神经病学杂志
不定期
2218-6212
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
48
总下载数(次)
0
总被引数(次)
0
论文1v1指导