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摘要:
AIM:To investigate the influence,if any,of tumor necrosis factor(TNF)-αinihibitors and Tocilizumab,on hepatic steatosis(HS)in rheumatoid arthritis(RA)patients in the light of the known role of TNF-αand interleukin-6,which are key-cytokines in the pathogenesis of RA,in inducing HS in general population.METHODS:We retrospectively reviewed the clinical charts of 36 RA patients,out of whom 12 had been treated with Methotrexate(MTX),12 with TNF inhibitors±MTX and 12 with Tocilizumab±MTX.The 3 subgroups of patients matched each other for sex,age,body mass index,metabolic syndrome(MS)and other risk factors for atherosclerosis.At baseline and after 12 mo each patient underwent an abdominal ultrasonog-raphy for the assessment of presence of HS and the evaluation of its grade.RESULTS:No difference was detected either in the prevalence of HS or in that of its distinct grades between the 3 groups of patients at baseline.After 12 mo,the HS grade unchanged in 20 patients(7 subjects treated with MTX,7 with TNF-αinhibitors±MTX and 6 Tocilizumab±MTX);increased in 12 patients(4 subjects treated with MTX,4 TNF-αblockers±MTX and 4 Tocilizumab±MTX);decreased in 4(1 treated with MTX,1 with anti-TNF-α+MTX and 2 with TCZ±MTX(P=0.75).No correlation was found between getting remission or low disease activity and the course of either MS or HS.CONCLUSION:We failed to detect any influence of MTX±TNF-αinhibitors or Tocilizumab in reducing MS and HS.A prospective study is needed to clarify the topic.
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篇名 TNF-αinhibitors and tocilizumab do not influence hepatic steatosis in patients with rheumatoid arthritis
来源期刊 世界风湿病学杂志 学科 医学
关键词 STEATOSIS RHEUMATOID ARTHRITIS Biological agents
年,卷(期) 2014,(1) 所属期刊栏目
研究方向 页码范围 1-5
页数 5页 分类号 R285.5
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STEATOSIS
RHEUMATOID
ARTHRITIS
Biological
agents
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世界风湿病学杂志
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2220-3214
北京市朝阳区东四环中路62号楼远洋国际中
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