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摘要:
Metabolomics has increasingly been applied in addition to other 'omic' approaches in the study of the pathophysiology of different gastrointestinal diseases.Metabolites represent molecular readouts of the cell status reflecting a physiological phenotype.In addition,changes in metabolite concentrations induced by exogenous factors such as environmental and dietary factors which do not affect the genome,are taken into account.Metabolic reactions initiated by the host or gut microbiota can lead to 'marker' metabolites present in different biological fluids that allow differentiation between health and disease.Several lines of evidence implicated the involvement of intestinal microbiota in the pathogenesis of inflammatory bowel disease(IBD).Also in irritable bowel syndrome(IBS),a role of an abnormal microbiota composition,so-called dysbiosis,is supported by experimental data.These compositional alterations could play a role in the aetiology of both diseases by altering the metabolic activities of the gut bacteria.Several studies have applied a metabolomic approach to identify these metabolite signatures.However,before translating a potential metabolite biomarker into clinical use,additional validation studies are required.This review summarizes contributions that metabolomics has made in IBD and IBS and presents potential future directions within the field.
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篇名 Metabolomics as a diagnostic tool in gastroenterology
来源期刊 世界胃肠药理与治疗学杂志:英文版(电子版) 学科 医学
关键词 Metabolomics MICROBIOTA Inflammatory BOWEL diseases IRRITABLE BOWEL syndrome
年,卷(期) 2013,(4) 所属期刊栏目
研究方向 页码范围 97-107
页数 11页 分类号 R574
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Metabolomics
MICROBIOTA
Inflammatory
BOWEL
diseases
IRRITABLE
BOWEL
syndrome
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世界胃肠药理与治疗学杂志:英文版(电子版)
双月刊
2150-5349
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
323
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0
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0
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