Potential of metastin and metastin receptor as biomarkers for urological cancers

Hakushi Kim; Haruhiro Sato; Koichi Takeya; Mayura Nakano; Shuichi Soeda; Sunao Shoji; Tetsuro Tomonaga; Toshiro Terachi; Toyoaki Uchida

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Potential of metastin and metastin receptor as biomarkers for urological cancers

Potential of metastin and metastin receptor as biomarkers for urological cancers

作者：

Hakushi Kim Haruhiro Sato Koichi Takeya Mayura Nakano Shuichi Soeda Sunao Shoji Tetsuro Tomonaga Toshiro Terachi Toyoaki Uchida

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KISS-1

METASTIN

RECEPTOR

Metastasis

Renal

cell

CARCINOMA

Upper

TRACT

UROTHELIAL

CARCINOMA

Bladder

cancer

摘要：

AIM:To investigate the current state of the research of metastin and metastin receptor in the urological cancer field.METHODS:For analyzing the value of metastin and metastin receptor as molecular biomarkers for the patients with urological cancer,MEDLINE database searches were performed using these terms:metastin,KISS1,kisspeptin,renal(cell)carcinoma(RCC),kidney cancer or urothelial cancer or bladder cancer or prostate cancer or testicular cancer(tumor).Since the articles were evaluated by the validity of the articles based on plausibility,credibility,and evidence levels,the articles were graded according to their level of evidence,using the grading system defined by the Oxford Centre for Evidence-based Medicine.RESULTS:A total of six clinical studies published by individual institutions between 2003 and 2013 were included in this review.The article numbers for each of the evidence levels 2a and 2b were three(50%)and three(50%),respectively.Immunohistochemistry and reverse transcriptase-polymerase chain reaction using tumor tissues were performed to analyze in five articles(83%)and in one article(17%).The value of metastin and/or metastin receptor as molecular biomarkers in clear cell RCC,upper tract urothelial carcinoma,and bladder cancer was evaluated by multivariate analysis.Low expression of metastin receptor in clear cell RCC and low expression of metastin in upper tract urothelial carcinoma were significant risk factors for metastasis,and low metastin expression was an independent prognostic factor in bladder cancer.CONCLUSION:Metastin and metastin receptor have potential as suitable molecular biomarkers for urological cancers.However,future studies of metastin and metastin receptor should undergo external validation to ensure consistency across different patient series,since individual institutional studies lack generalization.

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篇名	Potential of metastin and metastin receptor as biomarkers for urological cancers
来源期刊	世界临床泌尿杂志	学科	医学
关键词	KISS-1 METASTIN METASTIN RECEPTOR Metastasis Renal cell CARCINOMA Upper TRACT UROTHELIAL CARCINOMA Bladder cancer
年，卷（期）	2013,（2）	所属期刊栏目
研究方向		页码范围	10-14
页数	5页	分类号	R
字数		语种
DOI