Long-term survival of more than 3 years among patients with advanced non-small cell lung cancer treated with chemotherapy

Akira Ono; Asuka Tsuya; Haruyasu Murakami; Hirotsugu Kenmotsu; Kyoichi Kaira; Masahiro Endo; Nobuyuki Yamamoto; Rieko Kaira; Takehito Shukuya; Tateaki Naito; Toshiaki Takahashi; Yukiko Nakamura

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Long-term survival of more than 3 years among patients with advanced non-small cell lung cancer treated with chemotherapy

Long-term survival of more than 3 years among patients with advanced non-small cell lung cancer treated with chemotherapy

作者：

Akira Ono Asuka Tsuya Haruyasu Murakami Hirotsugu Kenmotsu Kyoichi Kaira Masahiro Endo Nobuyuki Yamamoto Rieko Kaira Takehito Shukuya Tateaki Naito Toshiaki Takahashi Yukiko Nakamura

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NON-SMALL

cell

lung

cancer

Long-term

SURVIVOR

CHEMOTHERAPY

Performance

status

EPIDERMAL

growth

factor

receptor-tyrosine

kinase

inhibitors

摘要：

AIM:To evaluate the prognostic factors of long-term survival of more than 3 years in patients with advanced non-small cell lung cancer(NSCLC).METHODS:We retrospectively analyzed the records of 474 patients with advancedⅢB/ⅣNSCLC who received chemotherapy as initial treatment between September 2002 and March 2007.RESULTS:The median survival time(MST)was 12.5 mo and the 3 year and 5 year survival rates were 14.6%and 5.3%,respectively.Long-term survival of more than 3 and 5 years was observed in 65 and 16 patients,respectively.The MST for the 65 patients was 61.5 mo(range,60.1-81.0 mo).In the 474 patients,a good performance status(PS),female sex,non-smoking status and adenocarcinoma histology were significantly associated with a favorable outcome.Furthermore,female sex,a good PS,non-smoking status and adenocarcinoma histology were significantly correlated with longterm survival of more than 3 years and most of these patients(89.2%,58/65)received epidermal growth factor receptor-tyrosine kinase inhibitors as any line treatment.Survival analysis of long-term survivors showed that a PS of 0 was an independent prognostic factor for predicting favorable outcomes.CONCLUSION:Our results suggest that a good PS and adenocarcinoma histology play an important role in long-term survival of more than 3 years.A PS of 0 was an independent prognostic factor for predicting favorable outcomes in patients with advanced NSCLC who survived for more than 3 years.

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篇名	Long-term survival of more than 3 years among patients with advanced non-small cell lung cancer treated with chemotherapy
来源期刊	世界呼吸病学杂志	学科	医学
关键词	NON-SMALL cell lung cancer Long-term SURVIVOR CHEMOTHERAPY Performance status EPIDERMAL growth factor receptor-tyrosine kinase inhibitors
年，卷（期）	2013,（3）	所属期刊栏目
研究方向		页码范围	110-115
页数	6页	分类号	R
字数		语种
DOI