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摘要:
Since early description of CD4/CD8 T cell duality,continuous discovery of functional T lymphocyte subsets and their related cytokines constitutes major progress in our understanding of the immune response.T-lymphocyte derived lymphokines and environmental cytokines are essential for both innate and antigen-specific immune responses to a wide variety of agents.Following immune battle and aggression overcome,cytokines may return against neighbored cells/organs,causing pathogenic hypersensitivity reactions,including autoimmune diseases.Due to their cytokine production,CD4+T helper lymphocyte subsets may be considered as one the major players of the immune response.Among CD4+T cell subsets,the identification of interleukin-17-producing cells(Th17)led to better understanding of coordinated cytokine involvement during inflammatory reactions together with the subsequent clarification of complex interactions between these mediators.In this review,we discuss Th17 cell differentiation,functions,and the role of this cell subset during rheumatoid arthritis pathogenesis together with therapeutic strategies to control these cells.
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篇名 Role of Th17 cells in the pathogenesis of rheumatoid arthritis
来源期刊 世界风湿病学杂志 学科 医学
关键词 Interleukin-17-producing CELLS CD4+T CELLS ARTHRITIS Inflammation BIOTHERAPY
年,卷(期) 2013,(3) 所属期刊栏目
研究方向 页码范围 25-31
页数 7页 分类号 R
字数 语种
DOI
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节点文献
Interleukin-17-producing
CELLS
CD4+T
CELLS
ARTHRITIS
Inflammation
BIOTHERAPY
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界风湿病学杂志
不定期
2220-3214
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
32
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0
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0
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