论文降重
免费查重- 钛学术文献服务平台 \
- 学术期刊 \
- 综合期刊 \
- 其它期刊 \
- 世界实验医学杂志期刊 \
Modulation of immune response in experimental Chagas disease
Modulation of immune response in experimental Chagas disease
基本信息来源于合作网站，原文需代理用户跳转至来源网站获取
摘要：
Trypanosoma cruzi(T.cruzi),the etiological agent of Chagas disease,affects nearly 18 million people in Latin America and 90 million are at risk of infection.The parasite presents two stages of medical importance in the host,the amastigote,intracellular replicating form,and the extracellular trypomastigote,the infective form.Thus infection by T.cruzi induces a complex immune response that involves effectors and regulatory mechanisms.That is why control of the infection requires a strong humoral and cellular immune response;hence,the outcome of host-parasite interaction in the early stages of infection is extremely important.A critical event during this period of the infection is innate immune response,in which the macrophage’s role is vital.Thus,after being phagocytized,the parasite is able to develop intracellularly;however,during later periods,these cells induce its elimination by means of toxic metabolites.In turn,as the infection progresses,adaptive immune response mechanisms are triggered through the TH1 and TH2 responses.Finally,T.cruzi,like other protozoa such as Leishmania and Toxoplasma,have numerous evasive mechanisms to the immune response that make it possible to spread around the host.In our Laboratory we have developed a vaccination model in mice with Trypanosoma rangeli,nonpathogenic to humans,which modulates the immune response to infection by T.cruzi,thus protecting them.Vaccinated animals showed an important innate response(modulation of NO and other metabolites,cytokines,activation of macrophages),a strong adaptive cellular response and significant increase in specific antibodies.The modulation caused early elimination of the parasites,low parasitaemia,the absence of histological lesions and high survival rates.Even though progress has been made in the knowledge of some of these mechanisms,new studies must be conducted which could target further prophylactic and therapeutic trials against T.cruzi infection.
推荐文章
免疫增殖性小肠病一例报告并文献复习
免疫增殖性小肠病
α-重链病
地中海淋巴瘤
肠梗阻
免疫增殖性小肠病一例报告并文献复习
免疫增殖性小肠病
α-重链病
地中海淋巴瘤
肠梗阻
免疫因子网络的Immune-B模型设计
Immune-B
因子网络
B方法
VC++
An experimental study of interaction between pure water and alkaline feldspar at high temperatures a
Alkaline feldspar
Autoclave
High-temperature and high-pressure experiments
内容分析
关键词云
关键词热度
相关文献总数
(/次)
(/年)
引文网络
引文网络
二级参考文献 (0)
共引文献 (0)
参考文献 (0)
节点文献
引证文献 (0)
同被引文献 (0)
二级引证文献 (0)
2013(0)
- 参考文献(0)
- 二级参考文献(0)
- 引证文献(0)
- 二级引证文献(0)
研究主题发展历程
节点文献
TRYPANOSOMA
CRUZI
CHAGAS
disease
INNATE
and
adaptive
IMMUNE
response
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界实验医学杂志
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2220-315X
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
邮发代号：
创刊时间：
语种：
出版文献量（篇）
90
总下载数（次）
0
总被引数（次）
0
期刊文献
相关文献
推荐文献
