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摘要:
Autotaxin(ATX or ENPP2)is a secreted glycoprotein widely present in biological fluids.ATX primarily functions as a plasma lysophospholipase D and is largely responsible for the bulk of lysophosphatidic acid(LPA)production in the plasma and at inflamed and/or malignant sites.LPA is a phospholipid mediator produced in various conditions both in cells and in biological fluids,and it evokes growth-factor-like responses,including cell growth,survival,differentiation and motility,in almost all cell types.The large variety of LPA effector functions is attributed to at least six G-protein coupled LPA receptors(LPARs)with overlapping specificities and widespread distribution.Increased ATX/LPA/LPAR levels have been detected in a large variety of cancers and transformed cell lines,as well as in non-malignant inflamed tissues,suggesting a possible involvement of ATX in chronic inflammatory disorders and cancer.In this review,we focus exclusively on the role of the ATX/LPA axis in pulmonary pathophysiology,analysing the effects of ATX/LPA on pulmonary cells and leukocytes in vitro and in the context of pulmonary pathophysiological situations in vivo and in human diseases.
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篇名 Autotaxin and lysophosphatidic acid signalling in lung pathophysiology
来源期刊 世界呼吸病学杂志 学科 医学
关键词 AUTOTAXIN Lysophosphatidic acid LUNG Acute LUNG injury PULMONARY FIBROSIS ASTHMA LUNG cancer
年,卷(期) 2013,(3) 所属期刊栏目
研究方向 页码范围 77-103
页数 27页 分类号 R
字数 语种
DOI
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研究主题发展历程
节点文献
AUTOTAXIN
Lysophosphatidic
acid
LUNG
Acute
LUNG
injury
PULMONARY
FIBROSIS
ASTHMA
LUNG
cancer
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界呼吸病学杂志
不定期
2218-6255
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
66
总下载数(次)
0
总被引数(次)
0
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