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Early chronic obstructive pulmonary disease:Beyond spirometry
Early chronic obstructive pulmonary disease:Beyond spirometry
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摘要：
The significant healthcare burden associated with chronic obstructive pulmonary disease(COPD)is driving us to improve our understanding of the natural history of this disease.Historically,the focus has been largely centred on diagnosing and treating individuals with moderate and severe disease.However,it is now recognised that the speed of decline in lung function as measured by forced expiratory volume in 1 s occurs faster in the earlier stages of the disease process.As a result,a clearer understanding of the potential benefits of treatment in early COPD is needed.It is recognised that many patients with COPD remain undiagnosed in the community which has prompted global case-finding initiatives.In this review we discuss the difficulties in diagnosing COPD in its early stages,examine the role of case-finding and look at the evidence for early intervention with therapeutic agents.There is a growing interest in the phenotypic variation amongst patients with COPD and we explore the role of phenotyping in early COPD and its potential benefits in providing a more individualised approach to COPD management.The majority of patients with COPD are known to die from non-respiratory causes such as cardiovascular disease.The mechanistic link is thought to relate to systemic inflammation,causing us to question whether earlier interventions could have a beneficial impact on the burden of co-morbidities for patients with COPD.
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节点文献
CHRONIC
obstructive
PULMONARY
DISEASE
CHRONIC
bronchitis
PULMONARY
emphysema
EARLY
DISEASE
Mild
CASE-FINDING
Phenotypes
Treatment
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研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界呼吸病学杂志
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2218-6255
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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出版文献量（篇）
66
总下载数（次）
0
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0
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