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Hypo-activity induced skeletal muscle atrophy and potential nutritional interventions:A review
Hypo-activity induced skeletal muscle atrophy and potential nutritional interventions:A review
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摘要：
Periods of hypo-activity result in profound changes in skeletal muscle morphology and strength.This review primarily addresses the differential impact of de-training,bed-rest,limb immobilisation and unilateral lower limb suspension on muscle morphology,strength and fatigability.The degree of muscle atrophy differs depending on the hypo-activity model and the muscles in question,with the leg and postural muscles being the most susceptible to atrophy.Hypo-activity also results in the dramatic loss of strength that often surpasses the loss of muscle mass,and consequently,the nervous system and contractile properties adapt to adjust for this excessive loss of strength.In addition,the degree of muscle strength loss is different depending on the hypo-activity model,with immobilisation appearing to have a greater impact on strength than unloaded models.There is a step-wise difference in the magnitude of muscle loss so that,even after accounting for differential durations of interventions immobilisation≥unilateral lower limb suspension≥bed-rest≥de-training.Muscle fatigability varies between hypoactivity models but the results are equivocal and this may be due to task-specific adaptations.This review also addresses potential nutritional interventions for attenuating hypo-activity induced muscle atrophy and strength declines,in the absence of exercise.Essential amino acid supplementation stands as a strong candidate but other supplements are good contenders for attenuating hypo-activity induced atrophy and strength losses.Several potential nutritional supplements are highlighted that could be used to combat muscle atrophy but extensive research is needed to determine the most effective.
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Immobilisation
DISUSE
MUSCLE
SIZE
MUSCLE
strength
NUTRITION
supplementation
MUSCLE
FATIGABILITY
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研究分支
研究去脉
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世界转化医学杂志
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百世登出版集团有限公司
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其它
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2220-6132
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出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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48
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0
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