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Experimental study of transient cochlear ischemi a as acause of sudden deafness
Experimental study of transient cochlear ischemi a as acause of sudden deafness
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摘要：
The etiology of sudden deafness or idiopathic suddensensorineural hearing loss （ISSHL） remains unclear.Over the past 15 years, we have investigated themechanisms of ischemic-induced hearing loss usinga gerbil model of transient cochlear ischemia. In thegerbil, cochlear ischemia can be induced by occludingthe bilateral vertebral arteries simultaneously at theneck, because the posterior communicating arteries ofthe Circle of Willis close spontaneously around 1 moafter birth. When 15 min ischemia was loaded on thisanimal, permanent hearing loss of about 25 dB andthe death of hair cells, especially inner hair cells wereinduced. These pathological changes were mainly dueto lack of an energy source, glutamate excitotoxicity,and the production of free radicals, especially superoxideand nitrous oxide species. Ischemic damage couldbe prevented by various procedures, such as coolingthe cochlea, intratympanic administration of insulin-likegrowth factor 1 or AM-111 （an anti-apoptotic agent）,and systemic administration of prednisolone （steroid）,edarabone （free radical scavenger）, ginsenoside Rb1（Kanpo）, hematopoietic stem cells, glia-cell derivedneurotrophic factor, and liposome-encapsulated hemoglobin（artificial red blood cells）. We also found that thecochlea was protected by the ischemic tolerance, indicating catingthat minor cochlear ischemia alleviates or preventsinner ear damage in subsequent severe cochlearischemia. As ISSHL usually occurs suddenly, with nopreceding sign or symptom, we suggest that most ISSHLcases are caused by circulatory disturbance, probablyat the stria vascularis.
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| 篇名 | Experimental study of transient cochlear ischemi a as acause of sudden deafness | ||
| 来源期刊 | 世界耳鼻咽喉科杂志 | 学科 | 医学 |
| 关键词 | Sudden DEAFNESS Occlusion of VERTEBRAL artery MONGOLIAN GERBIL Loss of inner hair cell Ischemic tolerance COCHLEAR HYPOTHERMIA | ||
| 年，卷（期） | 2013,（1） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 1-15 | |
| 页数 | 15页 | 分类号 | R7 |
| 字数 | 语种 | ||
| DOI | |||
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Sudden
DEAFNESS
Occlusion
of
VERTEBRAL
artery
MONGOLIAN
GERBIL
Loss
of
inner
hair
cell
Ischemic
tolerance
COCHLEAR
HYPOTHERMIA
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界耳鼻咽喉科杂志
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2218-6247
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
邮发代号：
创刊时间：
语种：
出版文献量（篇）
52
总下载数（次）
0
总被引数（次）
0
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