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Evidence,hypotheses and significance of MAP kinase TNNI3K interacting with its partners
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摘要：
TNNI3K is a cardiac-specific and cardiac troponin I(cTnI)-interacting MAP kinase,known to play important roles in promoting cardiac differentiation,maintenance of beating rhythm and contractual force.The molecular structure of TNNI3K contains three kinds of domain:a seven or ten NH2-terminal ankyrin repeat domain followed by a protein kinase domain and a COOH-terminal serine-rich domain.There are many binding sites in the structure of TNNI3K for binding to ATP,magnesium,nucleotide,protein kinase C,antioxidant protein 1(AOP-1)and cTnI,indicating TNNI3K has many interacting partners.This review summarizes the evidence,hypothesis and significance of TNNI3K interacting with TNNI3 and its other putative interaction partners.From the literature,the interaction partners of TNNI3K are divided into 2 types following their phenotypic pattern of functions,positive interaction(to increase the cardiac performance)or negative interaction(to suppress the cardiac performance).Following their binding sites,it also can be divided into other 2 types:binding to C-terminal domain(e.g.,cTnI)or binding to both ankyrin repeat domain and C-terminal domains(AOP-1).To date,a well understood partner of TNNI3K is cTnI,from the molecular structure,physiological function,mechanisms and its significance in some physiological and pathophysiological conditions.There are many reasons to believe that,with more understanding on the TNNI3K interacting with its partners,we can understand more roles of TNNI3K in some cardiac diseases.
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| 篇名 | Evidence,hypotheses and significance of MAP kinase TNNI3K interacting with its partners | ||
| 来源期刊 | 世界高血压杂志 | 学科 | 医学 |
| 关键词 | TNNI3K TNNI3 Cardiac-specific MAP kinase Velocity of DIASTOLIC DEPOLARIZATION Phosphorylation of cTnI Antioxidant PROTEIN 1 CALSEQUESTRIN CARDIAC hypertrophy Endothelin-1 CARDIAC myosin binding PROTEIN C | ||
| 年，卷（期） | 2012,（2） | 所属期刊栏目 | |
| 研究方向 | 页码范围 | 22-28 | |
| 页数 | 7页 | 分类号 | R |
| 字数 | 语种 | ||
| DOI | |||
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TNNI3K
TNNI3
Cardiac-specific
MAP
kinase
Velocity
of
DIASTOLIC
DEPOLARIZATION
Phosphorylation
of
cTnI
Antioxidant
PROTEIN
1
CALSEQUESTRIN
CARDIAC
hypertrophy
Endothelin-1
CARDIAC
myosin
binding
PROTEIN
C
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界高血压杂志
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2220-3168
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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创刊时间：
语种：
出版文献量（篇）
53
总下载数（次）
0
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0
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