论文降重
免费查重- 钛学术文献服务平台 \
- 学术期刊 \
- 综合期刊 \
- 其它期刊 \
- 世界实验医学杂志期刊 \
Immunology of tuberculosis
Immunology of tuberculosis
基本信息来源于合作网站，原文需代理用户跳转至来源网站获取
摘要：
are involved in the immunopathogenesis of tuberculosis(TB).A better understanding of immunology of TB can not only lead to the discovery of new immunodiagnostic tools,accelerate and facilitate the assessment of new therapeutic methods,but also find new treatment regimens.In this highlight topic we cover the latest developments in the role of T cells,macrophages,Natural killer(NK)cells,invariant NK T(iNKT)cells andγδT cells with TB infection.Histologically,TB displays exudative inflammation,proliferative inflammation and productive inflammation depending on the time course.T cells first recognize antigen within the mycobacterially-infected lung,and then activate,differentiate,but the first T cell activation occurs in the draining lymph nodes of the lung.When protective T cells reach sufficient numbers,they can stop bacterial growth.Except for T cells,neutrophils also participate actively in defense against early-phase TB.NK cells are innate lymphocytes which are a first line of defense against mycobacterial infection.Human NK cells use the NKp46,NCRs and NKG2D receptors to lyse Mycobacterium TB-infected monocytes and alveolar macrophages.NK cells produce not only interferon-γ,but also interleukin(IL)-22,which is induced by IL-15 and DAP-10.iNKT cells show different phenotypes and functions.Many iNKT cells are CD4+,few iNKT cells are CD8+,while an additional fraction of iNKT cells are negative for both CD4 and CD8.γδT cells represent an early innate defense in antimycobacterial immunity.Studies done in humans and animal models have demonstrated complex patterns ofγδT cell immune responses during chronic TB.Human alveolar macrophages and monocytes can serve as antigen presentation cells forγδT cells.Furthermore,the predominance of Vγ9Vδ2 T cells in TB has been confirmed.
推荐文章
广东省WHO结核病耐药监测研究
结核
药物耐受性
监测
广东
儿童哮喘的诊断和治疗:PRACTALL共识报告(待续)
诊断
教育
指南
监测
儿童哮喘
治疗
抗结核药物贝达喹啉的耐药情况及其耐药机制研究进展
结核
抗药性
贝达喹啉
综述文献（主题）
内容分析
关键词云
关键词热度
相关文献总数
(/次)
(/年)
引文网络
引文网络
二级参考文献 (0)
共引文献 (0)
参考文献 (0)
节点文献
引证文献 (0)
同被引文献 (0)
二级引证文献 (0)
2012(0)
- 参考文献(0)
- 二级参考文献(0)
- 引证文献(0)
- 二级引证文献(0)
研究主题发展历程
节点文献
MYCOBACTERIA
TUBERCULOSIS
IMMUNOLOGY
T
CELLS
Macrophages
Dendritic
CELLS
Invariant
natural
KILLER
T
cell
NEUTROPHILS
Cytokine
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界实验医学杂志
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2220-315X
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
邮发代号：
创刊时间：
语种：
出版文献量（篇）
90
总下载数（次）
0
总被引数（次）
0
期刊文献
相关文献
推荐文献
