Depression in adults with epilepsy:Relationship to psychobiological variables

Abdel-Rahman Mohamed Elsaied; Ahmad Abdel-Magid Soliman; Khalid Ahmad Mohamed; Mahmoud Mohamad Hassan; Mohamad Abdel-Rahman Ahmad; Nabil Abdel-Hakim Metwaly; Sherifa Ahmad Hamed

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Depression in adults with epilepsy:Relationship to psychobiological variables

Depression in adults with epilepsy:Relationship to psychobiological variables

作者：

Abdel-Rahman Mohamed Elsaied Ahmad Abdel-Magid Soliman Khalid Ahmad Mohamed Mahmoud Mohamad Hassan Mohamad Abdel-Rahman Ahmad Nabil Abdel-Hakim Metwaly Sherifa Ahmad Hamed

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ADRENALINE

ANTIEPILEPTIC

drugs

DEPRESSION

EPILEPSY

NORADRENALINE

SEROTONIN

摘要：

AIM:To characterize the relationship between depression and epilepsy-related seizures,treatment,hormonal and biological variables.METHODS:Included were 200 Egyptian adults(male=100,female=100)with epilepsy(mean age:30.87±7.88 years;duration of illness:13.89±7.64 years)and 100 healthy matched subjects for comparison.Psychiatric interview,Beck Depression Inventory(BDIII)and Hamilton Anxiety Rating Scale(HAM-A)were used to assess depression and anxiety.Blood levels of free testosterone,sex hormone binding globulin,prolactin,free thyroxin and thyroid stimulating hormone,serotonin,noradrenaline and adrenaline neurotransmitters were measured to assess endocrine and biological states.RESULTS:Patients had higher rates of depressive disorder(25.5%or 51/200),mostly intermixed with anxiety(47.06%),psychotic features(19.61%),aggression(40%)and suicide(55%).Compared to controls,higher scores on the BDI-II were observed with right-sided epileptic foci(P=0.011),polytherapy(P=0.001)and lack of control on antiepileptic drugs(AEDs)(P=0.0001).Patients had lower levels of serotonin(P=0.001)[marked with depression(P=0.012)]and adrenaline(P=0.0001),while noradrenaline was lower with temporal lobe epilepsy(P=0.039),left-sided foci(P=0.047)and lack of control on AEDs(P=0.017).Negative correlations were observed between levels of serotonin and BDI-II(P=0.048)and HAM-A(P=0.009)scores,but not with AEDs dose or drug level.CONCLUSION:Comorbid depressive disorder with epilepsy appears to be closely related to seizure type,focus,side,intractability to medications and neurotransmitter changes.Thus,optimizing seizure control and early recognition and management of depression is necessary to improve patients’quality of life.

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篇名	Depression in adults with epilepsy:Relationship to psychobiological variables
来源期刊	世界神经病学杂志	学科	医学
关键词	ADRENALINE ANTIEPILEPTIC drugs DEPRESSION EPILEPSY NORADRENALINE SEROTONIN
年，卷（期）	2012,（1）	所属期刊栏目
研究方向		页码范围	1-10
页数	10页	分类号	R
字数		语种
DOI