在 7T 的多原子的磁性的回声光谱学的应用

Antonio Napolitano; Frances Gunner; Ian A MacDonald; Mary C Stephenson; Nadeem Saeed; Paul L Greenhaff; Peter G Morris; Susan T Francis; William Vennart

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在 7T 的多原子的磁性的回声光谱学的应用

作者：

Antonio Napolitano Frances Gunner Ian A MacDonald Mary C Stephenson Nadeem Saeed Paul L Greenhaff Peter G Morris Susan T Francis William Vennart

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Magnetic

RESONANCE

SPECTROSCOPY

13C

TESLA

GLUTAMATE

GLUTAMINE

γ-aminobutyric

acid

摘要：

AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P 【 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies.

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篇名	在 7T 的多原子的磁性的回声光谱学的应用
来源期刊	世界放射学杂志：英文版（电子版）	学科	医学
关键词	Magnetic RESONANCE SPECTROSCOPY 13C 1H 7 TESLA GLUTAMATE GLUTAMINE γ-aminobutyric acid
年，卷（期）	2011,（4）	所属期刊栏目
研究方向		页码范围	105-113
页数	9页	分类号	R445.2
字数		语种
DOI