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Genome-wide association studies:Where we are heading?
Genome-wide association studies:Where we are heading?
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摘要：
wide association studies(GWAS)in recent years.Since the identification of variants in the complement factor H gene on the risk of age-related macular degeneration,GWAS have become ubiquitous in genetic studies and have led to the identification of genetic variants that are associated with a variety of complex human diseases and traits.These discoveries have changed our understanding of the biological architecture of common,complex diseases and have also provided new hypotheses to test.New tools,such as next-generation sequencing,will be an important part of the future of genetics research;however,GWAS studies will continue to play an important role in disease gene discovery.Many traits have yet to be explored by GWAS,especially in minority populations,and large collaborative studies are currently being conducted to maximize the return from existing GWAS data.In addition,GWAS technology continues to improve,increasing genomic coverage for major global populations and decreasing the cost of experiments.Although much of the variance attributable to genetic factors for many important traits is still unexplained,GWAS technology has been instrumental in mapping over a thousand genes to hundreds of traits.More discoveries are made each month and the scale,quality and quantity of current work has a steady trend upward.We briefly review the current key trends in GWAS,which can be summarized with three goals:increase power,increase collaborations and increase populations.
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研究主题发展历程
节点文献
GENOME-WIDE
association
studies
Single
NUCLEOTIDE
polymorphisms
Sequencing
GENOTYPE
IMPUTATION
Meta-analysis
Genetic
CONSORTIUM
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界医学遗传学杂志
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2220-3184
CN：
开本：
出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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创刊时间：
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出版文献量（篇）
39
总下载数（次）
0
总被引数（次）
0
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