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Genetic interactions in translational research on cancer
Genetic interactions in translational research on cancer
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摘要：
Genetic interactions are functional crosstalk among different genetic loci that lead to phenotypic changes,such as health or viability alterations.A disease or lethal phenotype that results from the combined effects of gene mutations at different loci is termed a synthetic sickness or synthetic lethality,respectively.Studies of genetic interaction have provided insight on the relationships among biochemical processes or pathways.Cancer results from genetic interactions and is a major focus of current studies in genetic interactions.Various basic and translational cancer studies have explored the concept of genetic interactions,including studies of the mechanistic characterization of genes,drug discovery,biomarker identification and the rational design of combination therapies.This review discusses the implications of genetic interactions in the development of personalized cancer therapies,the identification of treatment-responsive genes,the delineation of mechanisms of chemoresistance and the rational design of combined therapeutic strategies to overcome drug resistance.
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CANCER
DRUG
DISCOVERY
MUTATION
GENETIC
interaction
Target
identification
CHEMORESISTANCE
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研究分支
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世界医学遗传学杂志
主办单位：
百世登出版集团有限公司
出版周期：
不定期
ISSN：
2220-3184
CN：
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出版地：
北京市朝阳区东四环中路62号楼远洋国际中
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出版文献量（篇）
39
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0
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0
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