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摘要:
Unlike bone marrow(BM)mesenchymal stem cells(MSCs),whose in vivo identity has been actively explored in recent years,the biology of MSCs in the synovium remains poorly understood.Synovial MSCs may be of great importance to rheumatology and orthopedics because of the direct proximity and accessibility of the synovium to cartilage,ligament,and meniscus.Their excellent chondrogenic capabilities and suggested transit through the synovial fluid,giving unhindered access to the joint surface,further support a pivotal role for synovial MSCs in homeostatic joint repair.This review highlights several unresolved issues pertaining to synovial MSC isolation,topography,and their relationship with pericytes,synovial fibroblasts,and synovial fluid MSCs.Critically reviewing published data on synovial MSCs,we also draw from our experience of exploring the in vivo biology of MSCs in the BM to highlight key differences.Extending our knowledge of synovial MSCs in vivo could lead to novel therapeutic strategies for arthritic diseases.
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篇名 Synovial mesenchymal stem cells in vivo:Potential key players for joint regeneration
来源期刊 世界风湿病学杂志 学科 医学
关键词 MESENCHYMAL stem cells SYNOVIUM FIBROBLASTS SYNOVIAL fluid ARTHRITIS
年,卷(期) 2011,(1) 所属期刊栏目
研究方向 页码范围 4-11
页数 8页 分类号 R
字数 语种
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研究主题发展历程
节点文献
MESENCHYMAL
stem
cells
SYNOVIUM
FIBROBLASTS
SYNOVIAL
fluid
ARTHRITIS
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界风湿病学杂志
不定期
2220-3214
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
32
总下载数(次)
0
总被引数(次)
0
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