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摘要:
Alterations in calcium signaling and/or the expression of calcium pumps and channels are an increasingly recognized property of some cancer cells.Alterations in the expression of plasma membrane calcium ATPase(PMCA) isoforms have been reported in a variety of cancer types,including those of breast and colon,with some studies of cancer cell line differentiation identifying specific PMCA isoforms,which may be altered in some cancers.Some studies have also begun to assess levels of PMCA isoforms in clinical tumor samples and to address mechanisms of altered PMCA expression in cancers.Both increases and decreases in PMCA expression have been reported in different cancer types and in many cases these alterations are isoform specific.In this review,we provide an overview of studies investigating the expression of PMCA in cancer and discuss how both the overexpression and reduced expression of a PMCA isoform in a cancer cell could bestow a growth advantage,through augmenting responses to proliferative stimuli or reducing sensitivity to apoptosis.
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篇名 Plasma membrane calcium pumps and their emerging roles in cancer
来源期刊 世界生物化学杂志:英文版(电子版) 学科 医学
关键词 Plasma membrane CALCIUM ATPASE CALCIUM PUMP CANCER Expression TUMORIGENESIS
年,卷(期) 2010,(8) 所属期刊栏目
研究方向 页码范围 248-253
页数 6页 分类号 R730.2
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Plasma
membrane
CALCIUM
ATPASE
CALCIUM
PUMP
CANCER
Expression
TUMORIGENESIS
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世界生物化学杂志:英文版(电子版)
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1949-8454
北京市朝阳区东四环中路62号楼远洋国际中
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391
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0
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