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摘要:
With the increase in average life expectancy,the rate of occurrence of gastric cancer in elderly patients is also rising.While many clinical trials have been conducted to examine the effect of chemotherapy treatment on gastric cancer,age limits for eligible subjects have prevented the establishment of standards for chemotherapy in elderly patients with gastric cancer.As of March 2009,evidence-based standard chemotherapy regimens were established.In the Western world,debates centered on the ECF(Epirubicin/cisplatin/5FU) or DCF(Docetaxel/cisplatin/5-FU) regimens based on the phase □ randomized controlled trial at the Royal Marsden Hospital(RMH) or the V325 study,respectively.The JCOG9912 and SPIRITS trials emerged from Japan indicating attractive regimens that include S-1 for advanced gastric cancer patients.Using these active anticancer drugs,the trials that studied the eff icacy of adjuvant therapies or surgical approaches,such as the Int-116/MAGIC/ACTS-GC trials,have actually succeeded in demonstrating the benefits of adjuvant therapies in gastric cancer patients.For cases of gastric cancer in elderly patients,treatment policies should consider these studies while analyzing not only the therapeutic effects but also drug toxicity,individual general health conditions,and social factors to select treatments that emphasize quality of life.
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篇名 为在老病人的胃的癌症和临床的潜力的最新新兴的标准化疗
来源期刊 世界胃肠肿瘤学杂志:英文版(电子版) 学科 医学
关键词 GASTRIC cancer ELDERLY patients CHEMOTHERAPY REGIMEN comparison
年,卷(期) 2009,(1) 所属期刊栏目
研究方向 页码范围 47-54
页数 8页 分类号 R735.2
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GASTRIC
cancer
ELDERLY
patients
CHEMOTHERAPY
REGIMEN
comparison
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世界胃肠肿瘤学杂志:英文版(电子版)
月刊
1948-5204
北京市朝阳区东四环中路62号楼远洋国际中
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664
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