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摘要:
An efficient drug delivery is the prerequisite of the successful chemotherapeutic treatments of many human diseases. Despite a great number of approaches, the improvement of drug cell internalization remains an actual research challenge. We propose a new biological delivery system based on the extracellular vesicles released by a non-pathological eukaryotic microorganism, Dictyostelium discoideum. After a summary of the main characteristics of these extracellular vesicles, including of their lipid bilayer that appears as a good candidate for initiating membrane fusion, followed by delivery of their encapsulated drug, the capacity of these vesicles to convey drugs into human cells was demonstrated in vitro on two tumor cell lines, resistant leukaemia K562r and cervix carcinoma HeLa cells. A comparison with other extracellular vesicles, like exosomes or bacteria-derived particles, stresses the unique properties of Dictyostelium extracellular nanovesicles for drug delivery.
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篇名 A New Biological Strategy for Drug Delivery: Eucaryotic Cell-Derived Nanovesicles
来源期刊 生物材料与纳米技术(英文) 学科 医学
关键词 BIOLOGICAL EXTRACELLULAR Vesicles ANTITUMORAL Drug Delivery DICTYOSTELIUM DISCOIDEUM
年,卷(期) 2011,(5) 所属期刊栏目
研究方向 页码范围 494-499
页数 6页 分类号 R73
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研究主题发展历程
节点文献
BIOLOGICAL
EXTRACELLULAR
Vesicles
ANTITUMORAL
Drug
Delivery
DICTYOSTELIUM
DISCOIDEUM
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
生物材料与纳米技术(英文)
季刊
2158-7027
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
328
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0
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